A UK-based SME has developed proprietary technology to create personalised organ replacements. The tissue engineered products for trachea replacement and treatment of bronchopleural fistula are GMP and clincial-ready. The SME is looking for universities, hospitals and surgeons who will be able to conduct the clinical trials required to take the product to market. It is envisaged that the partnership will take the form of a technical cooperation or a research cooperation agreement.
Organ transplantation is a useful way of treating severe disease. However it has the two drawbacks of rejection due to tissue incompatibility between donor and recipient and availability of organs for transplantation in the first instance.
A UK-based SME has developed organ replacement technology aimed at addressing these problems. It has developed proprietary technology to produce biological scaffolds to which a patient's own stem cells are added, creating a personalised organ replacement available on demand and without risk of tissue incompatibility.
This has been furthest developed in the SME's tracheal replacement technology, which is also aimed at the treatment of life-threatening bronchopleural fistula. Donated human trachea are processed using SME's proprietary technology to remove cells and cellular remnants. Autologous mesenchymal stromal cells are used to reseed the decellularised tracheal scaffold, which is then used to replace the diseased portion of the patients trachea.
Good manufacturing practice (GMP) capability is in place for the trachea replacement product and the product has all required regulatory and ethical approvals necessary to commence clinical trials in the UK.
The SME is now looking to partner with universities, hospitals and surgeons in order to conduct clinical trials of their technology and enable them to take the technology to market. It is envisaged that the partnership will take the form of a technical cooperation agreement or a research cooperation agreement.
- Type of partner sought: The SME is looking to partner with universities, hospitals and surgeons who have experience in the regenerative medicine field and in particular with tissue / organ transplantation and diseases of the airways . In particular the SME is interested in potential partners with expertise or experience in relation to airway pathology and surgery
Partners with experience in conducting clinical trials in this field are especially sought.
- Specific area of activity of the partner: The UK SME is looking to partner with universities, hospitals and surgeons in order to carry out clinical trials of its trachea replacement technology. They are especially interested in making connections in the US, China and Japan but are open to all countries.
The SME will provide their technology to the partner for the purposes of conducting the clinical trial. The partner is expected to be able to conduct the trial including carrying out the required surgery.
It is envisaged that the partnership will take the form of a technical cooperation or a research cooperation agreement.