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TRNL20180531001

Optimization of therapeutic oligonucleotide efficacy for the treatment of solid tumours by innovative nanoparticles

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ABSTRACT

A Dutch clinical stage company is developing a new generation of nanomedicines. Their aim is to use their nanoparticle technology to improve the efficacy and safety profiles of current and novel drugs for the treatment of solid tumours.
As part of their development strategy, they are looking for a license and/or technical cooperation agreement with academic research labs to exploit their nanoparticles for enhanced tumour targeting of new oligonucleotides with therapeutic potential.


FULL DESCRIPTION

A Dutch clinical stage company developing a new generation of nanomedicines, aims to use their proprietary nanoparticle technology to improve the efficacy and safety profiles of current and novel drugs for the treatment of solid tumours.
In humans, their platform improves the pharmacokinetics and reduces life-threatening toxicities for drugs already used in the clinic. Moreover early signs of efficacy in humans have also been observed.
As part of the company’s development plan, they are looking for collaborative opportunities to exploit their nanoparticles for enhanced tumour targeting of new oligonucleotides with therapeutic potential.
Oligonucleotides, RNA (ribonucleic acid) or DNA (deoxyribonucleic acid), are of great therapeutic potential, as they may allow to act on to date undruggable targets, as well as utilising novel and unexplored mechanisms of action.
Despite this, selective tissue targeting of oligonucleotides has been a main challenge, as when administered naked they are unstable and may trigger undesired immunogenic responses. Effective targeting towards the appropriate intracellular compartment has also been a major hurdle thus far. These constraints have hampered the development of oligonucleotides in the clinic.
The company’s proprietary nanoparticle platform allows the entrapment of therapeutic molecules, to improve their pharmacokinetics upon intravenous (IV) or subcutaneous (SC) administration and to target them to cancer tissue where these molecules can be released extracellularly or intracellularly. The platform also offers the promise to target oligonucleotides to the applicable intracellular compartment. The client have generated initial in vivo proof of concept of enhanced oligonucleotide tumour targeting, cellular uptake, and knockdown of the target gene of interest.
To move forward the Dutch SME is looking for proprietary oligonucleotides having therapeutic potential that they can in-license and develop to the market in combination with their platform. The therapeutic candidate needs to fit the following criteria:
• Oligonucleotides having therapeutic potential for the treatment of solid tumours, e.g.:
? Gene expression modulating properties: siRNA (small interfering RNA), Antisense, shRNA (short hairpin RNA), miRNA (micro RNA), TFO (triplex forming oligonucleotides), or
? Immune stimulatory properties: CpG (C = cytosine triphosphate deoxynucleotide, p = phosphodiester link, G = guanine triphosphate deoxynucleotide), poly I:C (polyinosinic:polycytidylic acid) like oligonucleotides
? Other applicable mechanisms

The company is looking for a license and/or technical cooperation agreement with academic research labs to exploit their nanoparticles.


Partner expertise sought:

- Type of partner sought: Biomedicine/biotechnology academic research labs with proprietary oligonucleotides with therapeutic potential for the treatment of solid tumours. Potential collaborators and their oligonucleotide should fit the following criteria:
• Proof of concept at least in vitro but preferably in vivo in a cancer model
• Patent protected (filed after 2013), or be patentable
• Oligonucleotide project must be active
The Dutch company envisions a partnership in which the academic partner performs the in vitro and in vivo evaluations of the applicable oligonucleotides upon entrapment in optimized nanoparticles with the company’s input.
- Specific area of activity of the partner: The Dutch company is looking for a license agreement and/or a technical cooperation agreement with preferably an academic research lab that is open to licensing or partnering.
The SME envisions a partnership in which the academic partner performs the in vitro and in vivo evaluations of the applicable oligonucleotides upon entrapment in optimized nanoparticles with the company’s input.


Development Stage:

Under development/lab tested - Lead compound utilising the platform is approaching clinical phase II. Meanwhile, the broad applicability of the platform has been demonstrated with a variety of drug molecules Showcase oligonucleotide programme is in in vivo preclinical testing.


IPR:

Patent(s) applied for but not yet granted,Patents granted,Granted patent or patent application essential - The nanoparticle platform is patent protected and there is no interference with existing patents.

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KEY INFORMATION

Country of origin
NETHERLANDS
Profile date
11/06/2018
Deadline
12/06/2019

PARTNERSHIP(S) SOUGHT

License agreement Technical cooperation agreement

CLASSIFICATIONS

INDUSTRY SECTORS
Life Sciences \ Biosciences and Health \ Recycling & Waste Management \ Drug Discovery and Drug Development \ Diagnostics \ Medical Devices
TECHNOLOGY KEYWORDS
BIOLOGICAL SCIENCES / Medicine, Human Health / Clinical Research, Trials / BIOLOGICAL SCIENCES / Medicine, Human Health / Cytology, Cancerology, Oncology / BIOLOGICAL SCIENCES / Medicine, Human Health / Medical Research / BIOLOGICAL SCIENCES / Medicine, Human Health / Pharmaceutical Products / Drugs
COMMERCIAL KEYWORDS
Research and experimental development on biotechnology / Other human health activities
MARKET KEYWORDS
MEDICAL/HEALTH RELATED / Therapeutic / Drug delivery and other equipment / MEDICAL/HEALTH RELATED / Clinical Medicine / Oncology / MEDICAL/HEALTH RELATED / Other Medical/Health Related / Pharmaceuticals/fine chemicals

FIND OUT MORE

Contact Enterprise Europe Network Scotland by email at info@enterprise-europe-scotland.com, quoting reference number TRNL20180531001