A German research laboratory looks for industrial and research partners experienced in intravascular catheter-based application, toxicology, vascular wall immunology and pathology for a project under the H2020 call Regenerative medicine: from new insights to new applications. Aim of the project is to develop a method for preventing the pathologic dilatation of the aorta in case of aneurysms. The laboratory will induce the regeneration of elastin to finally stabilize the affected vessel sections.
Due to demographic change and the associated increase of elderly and multimorbid patients, an increase in thoracic and abdominal aortic aneurysm cases is to be expected. The current therapy is a continuous monitoring of progression. The inevitable progression of the disease increases the risk of rupture of the affected vessel over time. The rupture of the aorta often leads to strong and usually insatiable bleeding and can be fatal. Therefore, after reaching a diameter of > 5 cm, a preventive surgical procedure is required.
In order to tackle this problem a research laboratory of German university hospital is going to submit a proposal under the H2020 call SC1-BHC-07-2019 - Regenerative medicine: from new insights to new applications.
In this project, the research laboratory aims to induce the regeneration of elastin to stabilize the affected vessel wall. For this purpose, using the elastase-induced aneurysm model in rabbits, the stabilization of aneurysms and the progression will be investigated after the local administration of synthetic elastin-encoding mRNA (messenger RNA. Therefore, the synthetic mRNA complexed with a suitable transport vehicle is administered locally into the aorta and the protein synthesis of elastin is detected in elastase-induced aneurysm model in rabbits. At the beginning and 4 weeks after mRNA application, the change in vessel diameter is determined by sonography and angiography. Furthermore, treated vessel sections are examined histologically and by using ELISA (Enzyme-linked Immunosorbent Assay) and proteomics the production of elastin, immune responses, and change of tissue physiology are analyzed. The described project represents a promising method for preventing the pathologic dilatation of aorta and could make a severe surgery unnecessary and minimize the risk of rupture in the long term.
The laboratory is looking for partners for a reasearch co-operation agreement with expertise in:
-Intravascular catheter-based application
-Toxicologists in the above field
-Vascular wall immunology: specifically, TLR (toll-like receptor) activation
-Vessel wall pathology
Partners can be from academia and industry, SMEs with relevant track records in the respective fields are welcome.
It would also be suitable if one organisation has expertise in several tasks.
Deadline of the call – 16 April 2019
RIA Research and Innovation action
Budget – up to 6 million Euro
Deadline for expressions of interest – 22 February 2019
- Specific area of activity of the partner: Partners from academia and industry, also SMEs. They could be
-Specialists in intravascular catheter-based application
-Vascular wall immunologists: specifically, TLR (toll-like receptor) activation
-Vessel wall pathologists
Proposal under development
Granted patent or patent application essential
Evaluation scheme: single-stage
Coordinator required: No
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