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Summary

A company from Moscow, Russia, specialized in developing portable electromechanical biosensors, developed a prototype of pH-sensitive field effect transistor for express quantitative determination of bioactive compounds concentrations. The technology mitigates the problem of pH-sensor cells degradation during multiple use. The company is looking for partners for joint further development.

Full description

Nowadays, concurrent detection and measurement of bioactive substances concentration became extremely important in medicine, for human protection and civil security. Sequenators, based on sensor cells, identify violations in DNA molecules and proteins.
The main problem of analogues is degradation of pH-sensor cells during multiple use.
The company has developed a prototype of pH-sensitive field effect transistor, based on sensor cells sensitive to pH value. Such cells are implemented on a unified technological platform of integrate microelectronics and microsystem technique. The platform ensures the sensors high potential functional capabilities combined with simple signal transformation owing to innovative technical solutions. This approach helps to solve degradation problems and opens new possibilities of further miniaturization. Use of the sensor cells can extend the period of exploitation of sequencing equipment for genome interpretation.

Innovative Aspects

The innovation of the technology lays in original design solution based on multiple charge transfer.
The technology advantages are:
" high accuracy of measurements (±0,1 pH)
" capability of sequencing equipment operation with natural nucleotide (no special biochemical markers are needed)
" short time of detection
" simplicity of design solutions: no need to use lasers, expensive optics, cameras, fluorescence effect, enzymes stream for sequencing
" low cost of production and exploitation.

Partner expertise sought:

- Type of partner sought: IT industry

- Specific area of activity of the partner: developer of electrochemical biosensors

- Task to be performed by the partner sought: integration and coordination of experts with different specialization for development of elements of the technology for semiconductor sequencing